Ligand-enabled meta-C-H activation using a transient mediator.

ABSTRACT: Achieving site selectivity in C-H functionalization reactions is a significant challenge, especially when the target C-H bond is distant from existing functional groups. Coordination of a functional group to a metal is often a key driving force and control element in many important reactions including asymmetric hydrogenation, epoxidation and lithiation. Exploitation of this effect has led to the development of a broad range of directed C-H activation reactions. However, these C-H activation methods are limited to proximal C-H bonds, which are spatially and geometrically accessible from the directing functional group. The development of meta-selective C-H functionalizations remains a significant challenge. We recently developed a U-shaped template that can be used to overcome this constrai

SUBMITTER: Wang XC 

PROVIDER: S-EPMC4368492 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature