Mid-embryo patterning and precision in Drosophila segmentation: Kruppel dual regulation of hunchback.

ABSTRACT: In early development, genes are expressed in spatial patterns which later define cellular identities and tissue locations. The mechanisms of such pattern formation have been studied extensively in early Drosophila (fruit fly) embryos. The gap gene hunchback (hb) is one of the earliest genes to be expressed in anterior-posterior (AP) body segmentation. As a transcriptional regulator for a number of downstream genes, the spatial precision of hb expression can have significant effects in the development of the body plan. To investigate the factors contributing to hb precision, we used fine spatial and temporal resolution data to develop a quantitative model for the regulation of hb expression in the mid-embryo. In particular, modelling hb pattern refinement in mid nuclear cleavage cycle 14 (N

SUBMITTER: Holloway DM 

PROVIDER: S-EPMC4368514 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature