Sepsis induces specific changes in histone modification patterns in human monocytes.

ABSTRACT:

Background

Sepsis is a global burden and the primary cause of death in intensive care units worldwide. The pathophysiological changes induced by the host's systemic inflammatory response to infection are not yet fully understood. During sepsis, the immune system is confronted with a variety of factors, which are integrated within the individual cells and result in changes of their basal state of responsiveness. Epigenetic mechanisms like histone modifications are known to participate in the control of immune reactions, but so far the situation during sepsis is unknown.

Methods and findings

In a pilot approach, we performed combined chromatin immunoprecipitation followed by high-throughput sequencing to assess the genome-wide distribution of the chromatin modifications histon

SUBMITTER: Weiterer S 

PROVIDER: S-EPMC4368631 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature