Partial to complete suppression of unilateral noise-induced tinnitus in rats after cyclobenzaprine treatment.

ABSTRACT: Some forms of tinnitus are believed to arise from abnormal central nervous system activity following a single or repeated noise exposure, for which there are no widely accepted pharmacological treatments. One central site that could be related to tinnitus awareness or modulation is the locus coeruleus, a brainstem structure associated with stress, arousal, and attention. In the present study, we evaluated the effects of cyclobenzaprine, a drug known to act on the rat locus coeruleus, on noise-induced tinnitus using Gap Prepulse Inhibition of the Acoustic Startle (GPIAS). In untreated rats, brief silent gaps presented prior to a 5-10-kHz bandpass startling stimulus produced robust GPIAS. Treatment with cyclobenzaprine alone had no effect on the ability of gaps to suppress the startle respon

SUBMITTER: Lobarinas E 

PROVIDER: S-EPMC4368659 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature