Protein domain-level landscape of cancer-type-specific somatic mutations.

ABSTRACT: Identifying driver mutations and their functional consequences is critical to our understanding of cancer. Towards this goal, and because domains are the functional units of a protein, we explored the protein domain-level landscape of cancer-type-specific somatic mutations. Specifically, we systematically examined tumor genomes from 21 cancer types to identify domains with high mutational density in specific tissues, the positions of mutational hotspots within these domains, and the functional and structural context where possible. While hotspots corresponding to specific gain-of-function mutations are expected for oncoproteins, we found that tumor suppressor proteins also exhibit strong biases toward being mutated in particular domains. Within domains, however, we observed the expected pa

SUBMITTER: Yang F 

PROVIDER: S-EPMC4368709 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature