The subcortical cocktail problem; mixed signals from the subthalamic nucleus and substantia nigra.

ABSTRACT: The subthalamic nucleus and the directly adjacent substantia nigra are small and important structures in the basal ganglia. Functional magnetic resonance imaging studies have shown that the subthalamic nucleus and substantia nigra are selectively involved in response inhibition, conflict processing, and adjusting global and selective response thresholds. However, imaging these nuclei is complex, because they are in such close proximity, they can vary in location, and are very small relative to the resolution of most fMRI sequences. Here, we investigated the consistency in localization of these nuclei in BOLD fMRI studies, comparing reported coordinates with probabilistic atlas maps of young human participants derived from ultra-high resolution 7T MRI scanning. We show that the fMRI signal

SUBMITTER: de Hollander G 

PROVIDER: S-EPMC4368736 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature