Energy landscape reveals that the budding yeast cell cycle is a robust and adaptive multi-stage process.

ABSTRACT: Quantitatively understanding the robustness, adaptivity and efficiency of cell cycle dynamics under the influence of noise is a fundamental but difficult question to answer for most eukaryotic organisms. Using a simplified budding yeast cell cycle model perturbed by intrinsic noise, we systematically explore these issues from an energy landscape point of view by constructing an energy landscape for the considered system based on large deviation theory. Analysis shows that the cell cycle trajectory is sharply confined by the ambient energy barrier, and the landscape along this trajectory exhibits a generally flat shape. We explain the evolution of the system on this flat path by incorporating its non-gradient nature. Furthermore, we illustrate how this global landscape changes in response t

SUBMITTER: Lv C 

PROVIDER: S-EPMC4368831 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature