Pro-/antiinflammatory dysregulation in early psychosis: results from a 1-year follow-up study.

ABSTRACT:

Background

Previous studies indicated a systemic deregulation of the pro-/antiinflammatory balance in subjects after 6 months of a first psychotic episode. This disruption was reexamined 12 months after diagnosis to identify potential risk/protective factors and associations with symptom severity.

Methods

Eighty-five subjects were followed during 12 months and the determination of the same pro-/antiinflammatory mediators was carried out in plasma and peripheral blood mononuclear cells. Multivariate logistic regression analyses were used to identify risk/protective factors. Multiple linear regression models were performed to detect the change of each biological marker during follow-up in relation to clinical characteristics and confounding factors.

Results

This study s

SUBMITTER: Garcia-Bueno B 

PROVIDER: S-EPMC4368893 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature