DNA-Directed Polymerase Subunits Play a Vital Role in Human Telomeric Overhang Processing.

ABSTRACT:

Unlabelled

Telomeres consist of TTAGGG repeats bound by the shelterin complex and end with a 3' overhang. In humans, telomeres shorten at each cell division, unless telomerase (TERT) is expressed and able to add telomeric repeats. For effective telomere maintenance, the DNA strand complementary to that made by telomerase must be synthesized. Recent studies have discovered a link between different activities necessary to process telomeres in the S phase of the cell cycle to reform a proper overhang. Notably, the human CST complex (CTC1/STN1/TEN1), known to interact functionally with the polymerase complex (POLA/primase), was shown to be important for telomere processing. Here, focus was paid to the catalytic (POLA1/p180) and accessory (POLA2/p68) subunits of the polymerase, and thei

SUBMITTER: Diotti R 

PROVIDER: S-EPMC4369185 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature