Neuroanatomical differences in toddler boys with fragile x syndrome and idiopathic autism.

ABSTRACT:

Context

Autism is an etiologically heterogeneous neurodevelopmental disorder for which there is no known unifying etiology or pathogenesis. Many conditions of atypical development can lead to autism, including fragile X syndrome (FXS), which is presently the most common known single-gene cause of autism.

Objective

To examine whole-brain morphometric patterns that discriminate young boys with FXS from those with idiopathic autism (iAUT) as well as control participants.

Design

Cross-sectional, in vivo neuroimaging study.

Setting

Academic medical centers.

Patients

Young boys (n = 165; aged 1.57-4.15 years) diagnosed as having FXS or iAUT as well as typically developing and idiopathic developmentally delayed controls.

Main outcome measures

Univariate

SUBMITTER: Hoeft F 

PROVIDER: S-EPMC4369209 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature