Passive immunotherapy of tauopathy targeting pSer413-tau: a pilot study in mice.

ABSTRACT:

Objective

Cellular inclusions of hyperphosphorylated tau are a hallmark of tauopathies, which are neurodegenerative disorders that include Alzheimer's disease (AD). Active and passive immunization against hyperphosphorylated tau has been shown to attenuate phenotypes in model mice. We developed new monoclonal antibodies to hyperphosphorylated tau and sought high therapeutic efficacy for future clinical use.

Methods

Using more than 20 antibodies, we investigated which sites on tau are phosphorylated early and highly in the tauopathy mouse models tau609 and tau784. These mice display tau hyperphosphorylation, synapse loss, memory impairment at 6 months, and tangle formation and neuronal loss at 15 months. We generated mouse monoclonal antibodies to selected epitopes and examin

SUBMITTER: Umeda T 

PROVIDER: S-EPMC4369274 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature