Additive global cerebral blood flow normalization in arterial spin labeling perfusion imaging.

ABSTRACT: To determine how different methods of normalizing for global cerebral blood flow (gCBF) affect image quality and sensitivity to cortical activation, pulsed arterial spin labeling (pASL) scans obtained during a visual task were normalized by either additive or multiplicative normalization of modal gCBF. Normalization by either method increased the statistical significance of cortical activation by a visual stimulus. However, image quality was superior with additive normalization, whether judged by intensity histograms or by reduced variability within gray and white matter.

SUBMITTER: Stewart SB 

PROVIDER: S-EPMC4369335 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature