Survivin as a therapeutic target in Sonic hedgehog-driven medulloblastoma.

ABSTRACT: Medulloblastoma (MB) is a highly malignant brain tumor that occurs primarily in children. Although surgery, radiation and high-dose chemotherapy have led to increased survival, many MB patients still die from their disease, and patients who survive suffer severe long-term side effects as a consequence of treatment. Thus, more effective and less toxic therapies for MB are critically important. Development of such therapies depends in part on identification of genes that are necessary for growth and survival of tumor cells. Survivin is an inhibitor of apoptosis protein that regulates cell cycle progression and resistance to apoptosis, is frequently expressed in human MB and when expressed at high levels predicts poor clinical outcome. Therefore, we hypothesized that Survivin may have a criti

SUBMITTER: Brun SN 

PROVIDER: S-EPMC4369477 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature