Investigation of the vitamin D receptor polymorphisms in acromegaly patients.

ABSTRACT:

Objective

The genetic structural alterations in the majority of somatotroph adenomas are not clarified and the search for novel candidate genes is still a challenge. We aimed to investigate possible associations between vitamin D receptor (VDR) polymorphisms and acromegaly.

Design, patients, and methods

52 acromegaly patients (mean age 45.7 ± 1.9 years) and 83 controls (mean age 43.1 ± 2.6 years) were recruited to the study. VDR polymorphism was determined by polymerase chain reaction-based restriction fragment length polymorphism methods.

Results

The distribution of VDR genotypes showed a significant difference in the frequencies of VDR FokI genotypes between patients and controls (P = 0.034). VDR FokI ff genotype was significantly decreased in acromegaly patients (P

SUBMITTER: Ilhan M 

PROVIDER: S-EPMC4369882 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature