Arsenic Exposure, Arsenic Metabolism, and Incident Diabetes in the Strong Heart Study.

ABSTRACT:

Objective

Little is known about arsenic metabolism in diabetes development. We investigated the prospective associations of low-moderate arsenic exposure and arsenic metabolism with diabetes incidence in the Strong Heart Study.

Research design and methods

A total of 1,694 diabetes-free participants aged 45-75 years were recruited in 1989-1991 and followed through 1998-1999. We used the proportions of urine inorganic arsenic (iAs), monomethylarsonate (MMA), and dimethylarsinate (DMA) over their sum (expressed as iAs%, MMA%, and DMA%) as the biomarkers of arsenic metabolism. Diabetes was defined as fasting glucose ≥ 126 mg/dL, 2-h glucose ≥ 200 mg/dL, self-reported diabetes history, or self-reported use of antidiabetic medications.

Results

Over 11,263.2 person-years of

SUBMITTER: Kuo CC 

PROVIDER: S-EPMC4370323 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature