Lipoprotein particles and incident type 2 diabetes in the multi-ethnic study of atherosclerosis.

ABSTRACT:

Objective

In the Multi-Ethnic Study of Atherosclerosis (MESA), we evaluated associations of baseline levels of a lipoprotein-based insulin resistance (IR) index (LP-IR), IR-related lipoprotein particles, mean particle sizes, and lipids, with incident type 2 diabetes, independent of confounders, glucose, insulin, and HOMA-IR.

Research design and methods

Among 5,314 adults aged 45-84 years without baseline diabetes or cardiovascular disease, 656 cases of diabetes were identified during a mean follow-up of 7.7 years. Lipoprotein particle concentrations, size, and LP-IR were determined by nuclear magnetic resonance spectroscopy of stored baseline plasma. Potential effect modification, by race/ethnicity, sex, baseline use of lipid-lowering medications or hormone therapy, or gluco

SUBMITTER: Mackey RH 

PROVIDER: S-EPMC4370328 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature