Dyslipidemia and chronic inflammation markers are correlated with telomere length shortening in Cushing's syndrome.

ABSTRACT:

Introduction

Cushing's syndrome (CS) increases cardiovascular risk (CVR) and adipocytokine imbalance, associated with an increased inflammatory state. Telomere length (TL) shortening is a novel CVR marker, associated with inflammation biomarkers. We hypothesized that inflammatory state and higher CVR in CS might be related to TL shortening, as observed in premature aging.

Aim

To evaluate relationships between TL, CVR and inflammation markers in CS.

Methods

In a cross-sectional study, 77 patients with CS (14 males, 59 pituitary-, 17 adrenal- and 1 ectopic-origin; 21 active disease) and 77 age-, gender-, smoking-matched controls were included. Total white blood cell TL was measured by TRF-Southern technique. Clinical data and blood samples were collected (lipids, adrena

SUBMITTER: Aulinas A 

PROVIDER: S-EPMC4370384 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature