CXCR3 signaling in BRAFWT melanoma increases IL-8 expression and tumorigenicity.

ABSTRACT:

Unlabelled

Patients with early stage, radial growth phase (RGP) melanoma have a 97% survival rate; however, when the melanoma progresses to the invasive vertical growth phase (VGP), survival rates decrease to 15%. The targets of many clinical trials are the known genetic and molecular mechanisms involved in melanoma progression, with the most common oncogenic mutation being the BRAFV600E. However, less than half of melanomas harbor this mutation, and consequently, do not respond to the current BRAF targeted treatments. It is therefore critical to elucidate alternative mechanisms regulating melanoma progression. Increased expression of the chemokine receptor, CXCR3, on melanoma cells is correlated with increased metastasis and poor patient outcomes, suggesting a role for CXCR3 in th

SUBMITTER: Jenkins MH 

PROVIDER: S-EPMC4370421 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature