The 4'-hydroxyl group of resveratrol is functionally important for direct activation of PPARα.

ABSTRACT: Long-term moderate consumption of red wine is associated with a reduced risk of developing lifestyle-related diseases such as cardiovascular disease and cancer. Therefore, resveratrol, a constituent of grapes and various other plants, has attracted substantial interest. This study focused on one molecular target of resveratrol, the peroxisome proliferator activated receptor α (PPARα). Our previous study in mice showed that resveratrol-mediated protection of the brain against stroke requires activation of PPARα; however, the molecular mechanisms involved in this process remain unknown. Here, we evaluated the chemical basis of the resveratrol-mediated activation of PPARα by performing a docking mode simulation and examining the structure-activity relationships of various polyphenols. The res

SUBMITTER: Takizawa Y 

PROVIDER: S-EPMC4370454 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature