Genome-wide association study in an admixed case series reveals IL12A as a new candidate in Behcet disease.

ABSTRACT:

Introduction

The etiology of Behçet's disease (BD) is unknown, but widely considered an excessive T-cell mediated inflammatory response in a genetically susceptible host. Recent genome-wide association studies (GWAS) have shown limited number of novel loci-associations. The rarity and unequal distribution of the disease prevalence amongst different ethnic backgrounds have hampered the use of GWAS in cohorts of mixed ethnicity and sufficient sample size. However, novel statistical approaches have now enabled GWAS in admixed cohorts.

Methods

We ran a GWAS on 336 BD cases and 5,843 controls. The cases consisted of Western Europeans, Middle Eastern and Turkish individuals. Participants from the Generation R study, a multiethnic birth cohort in Rotterdam, The Netherlands were use

SUBMITTER: Kappen JH 

PROVIDER: S-EPMC4370488 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature