Personalized oncogenomics: clinical experience with malignant peritoneal mesothelioma using whole genome sequencing.

ABSTRACT: Peritoneal mesothelioma is a rare and sometimes lethal malignancy that presents a clinical challenge for both diagnosis and management. Recent studies have led to a better understanding of the molecular biology of peritoneal mesothelioma. Translation of the emerging data into better treatments and outcome is needed. From two patients with peritoneal mesothelioma, we derived whole genome sequences, RNA expression profiles, and targeted deep sequencing data. Molecular data were made available for translation into a clinical treatment plan. Treatment responses and outcomes were later examined in the context of molecular findings. Molecular studies presented here provide the first reported whole genome sequences of peritoneal mesothelioma. Mutations in known mesothelioma-related genes NF2, CDK

SUBMITTER: Sheffield BS 

PROVIDER: S-EPMC4370594 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature