Genetic mutations associated with isoniazid resistance in Mycobacterium tuberculosis: a systematic review.

ABSTRACT:

Background

Tuberculosis (TB) incidence and mortality are declining worldwide; however, poor detection of drug-resistant disease threatens to reverse current progress toward global TB control. Multiple, rapid molecular diagnostic tests have recently been developed to detect genetic mutations in Mycobacterium tuberculosis (Mtb) genes known to confer first-line drug resistance. Their utility, though, depends on the frequency and distribution of the resistance associated mutations in the pathogen population. Mutations associated with rifampicin resistance, one of the two first-line drugs, are well understood and appear to occur in a single gene region in >95% of phenotypically resistant isolates. Mutations associated with isoniazid, the other first-line drug, are more complex and occur

SUBMITTER: Seifert M 

PROVIDER: S-EPMC4370653 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature