Alternative polyadenylation allows differential negative feedback of human miRNA miR-579 on its host gene ZFR.

ABSTRACT: About half of the known miRNA genes are located within protein-coding host genes, and are thus subject to co-transcription. Accumulating data indicate that this coupling may be an intrinsic mechanism to directly regulate the host gene's expression, constituting a negative feedback loop. Inevitably, the cell requires a yet largely unknown repertoire of methods to regulate this control mechanism. We propose APA as one possible mechanism by which negative feedback of intronic miRNA on their host genes might be regulated. Using in-silico analyses, we found that host genes that contain seed matching sites for their intronic miRNAs yield longer 32UTRs with more polyadenylation sites. Additionally, the distribution of polyadenylation signals differed significantly between these host genes and hos

SUBMITTER: Hinske LC 

PROVIDER: S-EPMC4370670 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature