Genome-wide analysis of hepatic lipid content in extreme obesity.

ABSTRACT:

Aims

Individuals with type 2 diabetes have an increased risk of developing non-alcoholic fatty liver disease (NAFLD), and NAFLD patients are also at greater risk for developing type 2 diabetes. Although the relationship between type 2 diabetes and NAFLD is highly interconnected, the pathogenic mechanisms linking the two diseases are poorly understood. The goal of this study was to identify genetic determinants of hepatic lipid accumulation through association analysis using histological phenotypes in obese individuals.

Methods

Using the Illumina HumanOmniExpress BeadChip assay, we genotyped 2,300 individuals on whom liver biopsy data were available.

Results

We analyzed total bilirubin levels, which are linked to fatty liver in severe obesity, and observed the stronges

SUBMITTER: DiStefano JK 

PROVIDER: S-EPMC4370808 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature