Resting state networks distinguish human ventral tegmental area from substantia nigra.

ABSTRACT: Dopaminergic networks modulate neural processing across a spectrum of function from perception to learning to action. Multiple organizational schemes based on anatomy and function have been proposed for dopaminergic nuclei in the midbrain. One schema originating in rodent models delineated ventral tegmental area (VTA), implicated in complex behaviors like addiction, from more lateral substantia nigra (SN), preferentially implicated in movement. However, because anatomy and function in rodent midbrain differs from the primate midbrain in important ways, the utility of this distinction for human neuroscience has been questioned. We asked whether functional definition of networks within the human dopaminergic midbrain would recapitulate this traditional anatomical topology. We first developed

SUBMITTER: Murty VP 

PROVIDER: S-EPMC4370842 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature