Development and characterization of sorbitan monostearate and sesame oil-based organogels for topical delivery of antimicrobials.

ABSTRACT: The current study explains the development of sorbitan monostearate and sesame oil-based organogels for topical drug delivery. The organogels were prepared by dissolving sorbitan monostearate in sesame oil (70°C). Metronidazole was used as a model antimicrobial. The formulations were characterized using phase contrast microscopy, infrared spectroscopy, viscosity, mechanical test, and differential scanning calorimetry. Phase contrast microscopy showed the presence of needle-shaped crystals in the organogel matrix. The length of the crystals increased with the increase in the sorbitan monostearate concentration. XRD studies confirmed the amorphous nature of the organogels. Viscosity study demonstrated shear thinning behavior of the organogels. The viscosity and the mechanical properties of t

SUBMITTER: Singh VK 

PROVIDER: S-EPMC4370955 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature