Roller compaction of hydrophilic extended release tablets-combined effects of processing variables and drug/matrix former particle size.

ABSTRACT: The present study shows that roller compaction (RC) can successfully be used as a granulation method to prepare hydroxypropyl methylcellulose (HPMC)-based extended release matrix tablets containing a high drug load, both for materials deforming mainly by fragmentation (paracetamol) as for those having mainly plastic deformation (ibuprofen). The combined effect of RC process variables and composition on the manufacturability of HPMC tablets was investigated. Standard wet granulation grade HPMC was compared with a larger particle size direct compressible HPMC grade. Higher roll pressure was found to result in larger paracetamol granules and narrower granule particle size distributions, especially for formulations containing smaller size HPMC. However, for ibuprofen, no clear effect of roll p

SUBMITTER: Heiman J 

PROVIDER: S-EPMC4370971 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature