Entrainment of heterogeneous glycolytic oscillations in single cells.

ABSTRACT: Cell signaling, gene expression, and metabolism are affected by cell-cell heterogeneity and random changes in the environment. The effects of such fluctuations on cell signaling and gene expression have recently been studied intensively using single-cell experiments. In metabolism heterogeneity may be particularly important because it may affect synchronisation of metabolic oscillations, an important example of cell-cell communication. This synchronisation is notoriously difficult to describe theoretically as the example of glycolytic oscillations shows: neither is the mechanism of glycolytic synchronisation understood nor the role of cell-cell heterogeneity. To pin down the mechanism and to assess its robustness and universality we have experimentally investigated the entrainment of glyco

SUBMITTER: Gustavsson AK 

PROVIDER: S-EPMC4371117 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature