Head injury and risk for Parkinson disease: results from a Danish case-control study.

ABSTRACT:

Objective

To examine the association between head injuries throughout life and the risk for Parkinson disease (PD) in an interview-based case-control study.

Methods

We identified 1,705 patients diagnosed with PD at 10 neurologic centers in Denmark in 1996-2009 and verified their diagnoses in medical records. Patients were matched to 1,785 controls randomly selected from the Danish Central Population Register on sex and year of birth. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression.

Results

We observed no association between any head injury before first cardinal symptom and PD (OR 1.02; 95% CI 0.88, 1.19). Examination of number of head injuries (1: OR 1.02; 95% CI 0.87, 1.20; ≥2: OR 1.03; 95% CI 0.72, 1.47) or

SUBMITTER: Kenborg L 

PROVIDER: S-EPMC4371406 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature