Parkinson risk in idiopathic REM sleep behavior disorder: preparing for neuroprotective trials.

ABSTRACT:

Objective

To precisely delineate clinical risk factors for conversion from idiopathic REM sleep behavior disorder (RBD) to Parkinson disease, dementia with Lewy bodies, and multiple system atrophy, in order to enable practical planning and stratification of neuroprotective trials against neurodegenerative synucleinopathy.

Methods

In a 10-year prospective cohort, we tested prodromal Parkinson disease markers in 89 patients with idiopathic RBD. With Kaplan-Meier analysis, we calculated risk of neurodegenerative synucleinopathy, and using Cox proportional hazards, tested the ability of prodromal markers to identify patients at higher disease risk. By combining predictive markers, we then designed stratification strategies to optimally select patients for definitive neuroprotect

SUBMITTER: Postuma RB 

PROVIDER: S-EPMC4371408 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature