Effects of vascular risk factors and APOE ε4 on white matter integrity and cognitive decline.

ABSTRACT:

Objective

To investigate the effects of vascular risk factors and APOE status on white matter microstructure, and subsequent cognitive decline among older people.

Methods

This study included 241 participants (age 60 years and older) from the population-based Swedish National Study on Aging and Care in Kungsholmen in central Stockholm, Sweden, who were free of dementia and stroke at baseline (2001-2004). We collected data through interviews, clinical examinations, and laboratory tests. We measured fractional anisotropy (FA) and mean diffusivity (MD) on diffusion tensor imaging, and estimated volume of white matter hyperintensities using automatic segmentation. We assessed global cognitive function with the Mini-Mental State Examination at baseline and at 3- and/or 6-year foll

SUBMITTER: Wang R 

PROVIDER: S-EPMC4371409 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature