Population pharmacokinetics of ampicillin and sulbactam in patients with community-acquired pneumonia: evaluation of the impact of renal impairment.

ABSTRACT:

Aims

The aims of this study were to develop a population pharmacokinetic (PK) model of ampicillin and sulbactam, to identify patient characteristics influencing the PK, and to explore the relationship between dose regimen and degree of renal impairment with exposure and time above minimum inhibitory concentration (MIC).

Methods

This analysis was performed on PK data for ampicillin and sulbactam and MIC data from a clinical trial in Japanese patients with community acquired pneumonia. Simulations were performed to investigate the effects of different dosing intervals on exposure and time above MIC in various degrees of renal impairment.

Results

The plasma concentrations from 47 patients were adequately described by a two compartment model with simultaneous fit of ampic

SUBMITTER: Soto E 

PROVIDER: S-EPMC4371533 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature