Polymorphism in the protease-activated receptor-4 gene region associates with platelet activation and perioperative myocardial injury.

ABSTRACT: Protease-activated receptors (PAR)-1 and -4 are the principal receptors for thrombin-mediated platelet activation. Functional genetic variation has been described in the human PAR1 gene, but not in the PAR4 gene (F2RL3). We sought to identify variants in and around F2RL3 and to determine their association with perioperative myocardial injury (PMI) after coronary artery bypass graft surgery. We further explored possible mechanisms for F2RL3 single nucleotide polymorphism (SNP) associations with PMI including altered receptor expression and platelet activation. Twenty-three SNPs in the F2RL3 gene region were genotyped in two phases in 934 Caucasian subjects. Platelets from 43 subjects (23 major allele, 20 risk allele) homozygous for rs773857 (SNP with the strongest association with PMI) unde

SUBMITTER: Muehlschlegel JD 

PROVIDER: S-EPMC4371854 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature