Genome-wide regulatory dynamics of translation in the Plasmodium falciparum asexual blood stages.

ABSTRACT: The characterization of the transcriptome and proteome of Plasmodium falciparum has been a tremendous resource for the understanding of the molecular physiology of this parasite. However, the translational dynamics that link steady-state mRNA with protein levels are not well understood. In this study, we bridge this disconnect by measuring genome-wide translation using ribosome profiling, through five stages of the P. falciparum blood phase developmental cycle. Our findings show that transcription and translation are tightly coupled, with overt translational control occurring for less than 10% of the transcriptome. Translationally regulated genes are predominantly associated with merozoite egress functions. We systematically define mRNA 5' leader sequences, and 3' UTRs, as we

SUBMITTER: Caro F 

PROVIDER: S-EPMC4371882 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature