Sustained Aeration of Infant Lungs (SAIL) trial: study protocol for a randomized controlled trial.

ABSTRACT:

Background

Extremely preterm infants require assistance recruiting the lung to establish a functional residual capacity after birth. Sustained inflation (SI) combined with positive end expiratory pressure (PEEP) may be a superior method of aerating the lung compared with intermittent positive pressure ventilation (IPPV) with PEEP in extremely preterm infants. The Sustained Aeration of Infant Lungs (SAIL) trial was designed to study this question.

Methods/design

This multisite prospective randomized controlled unblinded trial will recruit 600 infants of 23 to 26 weeks gestational age who require respiratory support at birth. Infants in both arms will be treated with PEEP 5 to 7 cm H2O throughout the resuscitation. The study intervention consists of performing an initial SI (2

SUBMITTER: Foglia EE 

PROVIDER: S-EPMC4372179 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature