Restrictive versus liberal transfusion strategy for red blood cell transfusion: systematic review of randomised trials with meta-analysis and trial sequential analysis.

ABSTRACT:

Objective

To compare the benefit and harm of restrictive versus liberal transfusion strategies to guide red blood cell transfusions.

Design

Systematic review with meta-analyses and trial sequential analyses of randomised clinical trials.

Data sources

Cochrane central register of controlled trials, SilverPlatter Medline (1950 to date), SilverPlatter Embase (1980 to date), and Science Citation Index Expanded (1900 to present). Reference lists of identified trials and other systematic reviews were assessed, and authors and experts in transfusion were contacted to identify additional trials.

Trial selection

Published and unpublished randomised clinical trials that evaluated a restrictive compared with a liberal transfusion strategy in adults or children, irrespecti

SUBMITTER: Holst LB 

PROVIDER: S-EPMC4372223 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature