Obesity and risk of bladder cancer: a dose-response meta-analysis of 15 cohort studies.

ABSTRACT:

Background

Epidemiological studies have reported inconsistent association between obesity and risk of bladder cancer, and the dose-response relationship between them has not been clearly defined.

Methods

We carried out a meta-analysis to summarize available evidence from epidemiological studies on this point. Relevant articles were identified by searching the PubMed and Web of Science databases through September 30, 2014. We pooled the relative risks from individual studies using random-effect model, and the dose-response relationship was estimated by using restricted cubic spline model.

Results

Fifteen cohort studies with 38,072 bladder cancer cases among 14,201,500 participants were included. Compared to normal weight, the pooled relative risks and corresponding 95%

SUBMITTER: Sun JW 

PROVIDER: S-EPMC4372289 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature