Midkine-a protein localization in the developing and adult retina of the zebrafish and its function during photoreceptor regeneration.

ABSTRACT: Midkine is a heparin binding growth factor with important functions in neuronal development and survival, but little is known about its function in the retina. Previous studies show that in the developing zebrafish, Midkine-a (Mdka) regulates cell cycle kinetics in retinal progenitors, and following injury to the adult zebrafish retina, mdka is strongly upregulated in Müller glia and the injury-induced photoreceptor progenitors. Here we provide the first data describing Mdka protein localization during different stages of retinal development and during the regeneration of photoreceptors in adults. We also experimentally test the role of Mdka during photoreceptor regeneration. The immuno-localization of Mdka reflects the complex spatiotemporal pattern of gene expression and also reveals the

SUBMITTER: Gramage E 

PROVIDER: S-EPMC4372396 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature