Validation of serological tests for the detection of antibodies against Treponema pallidum in nonhuman primates.

ABSTRACT: There is evidence to suggest that the yaws bacterium (Treponema pallidum ssp. pertenue) may exist in non-human primate populations residing in regions where yaws is endemic in humans. Especially in light of the fact that the World Health Organizaiton (WHO) recently launched its second yaws eradication campaign, there is a considerable need for reliable tools to identify treponemal infection in our closest relatives, African monkeys and great apes. It was hypothesized that commercially available serological tests detect simian anti-T. pallidum antibody in serum samples of baboons, with comparable sensitivity and specificity to their results on human sera. Test performances of five different treponemal tests (TTs) and two non-treponemal tests (NTTs) were evaluated using serum samples of 57 n

SUBMITTER: Knauf S 

PROVIDER: S-EPMC4372418 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature