Rates of decline in regions of the visual field defined by frequency-domain optical coherence tomography in patients with RPGR-mediated X-linked retinitis pigmentosa.

ABSTRACT:

Purpose

To determine whether annual decline in visual field sensitivity is greater in the transition zone at the edge of the frequency-domain optical coherence tomography (fdOCT) inner segment ellipsoid zone (EZ) than at other locations in the visual field.

Design

Prospective, longitudinal, observational study.

Participants

Forty-four patients with X-linked retinitis pigmentosa (XLRP) resulting from a mutation in the RPGR gene.

Methods

Static perimetric fields (Humphrey 30-2; Carl Zeiss Meditec, Dublin, CA) were obtained annually for 4 years. Beginning with year 2, fdOCT scans were obtained annually with a Heidelberg Spectralis HRA + OCT (Heidelberg Engineering, Heidelberg, Germany).

Main outcome measures

The rate of visual field decline at locations nea

SUBMITTER: Birch DG 

PROVIDER: S-EPMC4372456 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature