Growth of geographic atrophy in the comparison of age-related macular degeneration treatments trials.

ABSTRACT:

Purpose

To evaluate the growth of geographic atrophy (GA) during anti-vascular endothelial growth factor (VEGF) therapy.

Design

Cohort within a clinical trial.

Participants

Patients included in the Comparison of Age-related Macular Degeneration Treatments Trials (CATT).

Methods

Participants were randomly assigned to injections of ranibizumab or bevacizumab and to a 2-year dosing regimen of monthly or pro re nata (PRN) or to monthly for 1 year and PRN the following year. Digital color photographs and fluorescein angiograms at baseline and 1 and 2 years were evaluated for GA, and the total area of GA was measured by 2 graders masked to treatment; differences were adjudicated. Multivariate linear mixed models of the annual change in the square root of the area inc

SUBMITTER: Grunwald JE 

PROVIDER: S-EPMC4372487 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature