Targeted screening of individuals at high risk for pancreatic cancer: results of a simulation model.

ABSTRACT:

Purpose

To identify when, from the standpoint of relative risk, magnetic resonance (MR) imaging-based screening may be effective in patients with a known or suspected genetic predisposition to pancreatic cancer.

Materials and methods

The authors developed a Markov model of pancreatic ductal adenocarcinoma (PDAC). The model was calibrated to National Cancer Institute Surveillance, Epidemiology, and End Results registry data and informed by the literature. A hypothetical screening strategy was evaluated in which all population individuals underwent one-time MR imaging screening at age 50 years. Screening outcomes for individuals with an average risk for PDAC ("base case") were compared with those for individuals at an increased risk to assess for differential benefits in popul

SUBMITTER: Pandharipande PV 

PROVIDER: S-EPMC4372492 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature