TBK1 gene duplication and normal-tension glaucoma.

ABSTRACT:

Importance

Normal-tension glaucoma (NTG) is a common cause of vision loss.

Objective

To investigate the role of TANK binding kinase 1 (TBK1) gene duplications in NTG to gain insights into the causes of glaucoma that occurs at low intraocular pressure (IOP).

Design, setting, and participants

In this multicenter case-control study, we investigated patients who met the criteria for NTG, including glaucomatous optic neuropathy, visual field defects, and maximum recorded untreated IOP of 21 mm Hg or less, and matched controls. Participants (N = 755) were recruited from Southampton, United Kingdom (180 patients and 178 controls), Rochester, Minnesota (65 patients and 12 controls), New York, New York (96 patients and 16 controls), and Iowa City, Iowa (208 controls).

Main

SUBMITTER: Ritch R 

PROVIDER: S-EPMC4372533 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature