Metabolomic characteristics of arsenic-associated diabetes in a prospective cohort in Chihuahua, Mexico.

ABSTRACT: Chronic exposure to inorganic arsenic (iAs) has been linked to an increased risk of diabetes, yet the specific disease phenotype and underlying mechanisms are poorly understood. In the present study we set out to identify iAs exposure-associated metabolites with altered abundance in nondiabetic and diabetic individuals in an effort to understand the relationship between exposure, metabolomic response, and disease status. A nested study design was used to profile metabolomic shifts in urine and plasma collected from 90 diabetic and 86 nondiabetic individuals matched for varying iAs concentrations in drinking water, body mass index, age, and sex. Diabetes diagnosis was based on measures of fasting plasma glucose and 2-h blood glucose. Multivariable models were used to identify metabolites wi

SUBMITTER: Martin E 

PROVIDER: S-EPMC4372663 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature