Identification and regulation of a novel Citrobacter rodentium gut colonization fimbria (Gcf).

ABSTRACT:

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The Gram-negative enteric bacterium Citrobacter rodentium is a natural mouse pathogen that has been extensively used as a surrogate model for studying the human pathogens enteropathogenic and enterohemorrhagic Escherichia coli. All three pathogens produce similar attaching and effacing (A/E) lesions in the intestinal epithelium. During infection, these bacteria employ surface structures called fimbriae to adhere and colonize the host intestinal epithelium. For C. rodentium, the roles of only a small number of its genome-carried fimbrial operons have been evaluated. Here, we report the identification of a novel C. rodentium colonization factor, called gut colonization fimbria (Gcf), which is encoded by a chaperone-usher fimbrial operon. A gcfA mutant shows a severe coloni

SUBMITTER: Caballero-Flores GG 

PROVIDER: S-EPMC4372744 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature