The Escherichia coli membrane protein insertase YidC assists in the biogenesis of penicillin binding proteins.

ABSTRACT:

Unlabelled

Membrane proteins need to be properly inserted and folded in the membrane in order to perform a range of activities that are essential for the survival of bacteria. The Sec translocon and the YidC insertase are responsible for the insertion of the majority of proteins into the cytoplasmic membrane. YidC can act in combination with the Sec translocon in the insertion and folding of membrane proteins. However, YidC also functions as an insertase independently of the Sec translocon for so-called YidC-only substrates. In addition, YidC can act as a foldase and promote the proper assembly of membrane protein complexes. Here, we investigate the effect of Escherichia coli YidC depletion on the assembly of penicillin binding proteins (PBPs), which are involved in cell wall synth

SUBMITTER: de Sousa Borges A 

PROVIDER: S-EPMC4372751 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature