Randomized exercise trial of aromatase inhibitor-induced arthralgia in breast cancer survivors.

ABSTRACT:

Purpose

Arthralgia occurs in up to 50% of breast cancer survivors treated with aromatase inhibitors (AIs) and is the most common reason for poor AI adherence. We conducted, in 121 breast cancer survivors receiving an AI and reporting arthralgia, a yearlong randomized trial of the impact of exercise versus usual care on arthralgia severity.

Patients and methods

Eligibility criteria included receiving an AI for at least 6 months, reporting ≥ 3 of 10 for worst joint pain on the Brief Pain Inventory (BPI), and reporting < 90 minutes per week of aerobic exercise and no strength training. Participants were randomly assigned to exercise (150 minutes per week of aerobic exercise and supervised strength training twice per week) or usual care. The BPI, Western Ontario and McMaster Uni

SUBMITTER: Irwin ML 

PROVIDER: S-EPMC4372849 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature