Integrative epigenomic analysis of differential DNA methylation in urothelial carcinoma.

ABSTRACT:

Background

Urothelial carcinoma of the bladder (UC) is a common malignancy. Although extensive transcriptome analysis has provided insights into the gene expression patterns of this tumor type, the mechanistic underpinnings of differential methylation remain poorly understood. Multi-level genomic data may be used to profile the regulatory potential and landscape of differential methylation in cancer and gain understanding of the processes underlying epigenetic and phenotypic characteristics of tumors.

Methods

We perform genome-wide DNA methylation profiling of 98 gene-expression subtyped tumors to identify between-tumor differentially methylated regions (DMRs). We integrate multi-level publically available genomic data generated by the ENCODE consortium to characterize the r

SUBMITTER: Aine M 

PROVIDER: S-EPMC4373102 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature