Oxidative DNA damage in diabetic and mild gestational hyperglycemic pregnant women.

ABSTRACT:

Background

Pregnant women with mild gestational hyperglycemia present high risk for hypertension, obesity and hyperglycemia, and appeared to reproduce the model of metabolic syndrome in pregnancy, with hyperinsulinemia and insulin resistance. Our clinical studies showed that mild gestational hyperglycemia or gestational diabetes are related to similar adverse maternal and perinatal outcomes. Hyperglycemia and other factors associated with diabetes generate reactive oxygen species that increase DNA damage levels. The aim of this study was to evaluate oxidative DNA damage in lymphocytes of pregnant women with diabetes or mild gestational hyperglycemia.

Methods

The study included 111 pregnant women distributed into three groups based on oral glucose tolerance test (OGTT) and gl

SUBMITTER: Gelaleti RB 

PROVIDER: S-EPMC4373109 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature