An efficient weighted tag SNP-set analytical method in genome-wide association studies.

ABSTRACT:

Background

Single-nucleotide polymorphism (SNP)-set analysis in Genome-wide association studies (GWAS) has emerged as a research hotspot for identifying genetic variants associated with disease susceptibility. But most existing methods of SNP-set analysis are affected by the quality of SNP-set, and poor quality of SNP-set can lead to low power in GWAS.

Results

In this research, we propose an efficient weighted tag-SNP-set analytical method to detect the disease associations. In our method, we first design a fast algorithm to select a subset of SNPs (called tag SNP-set) from a given original SNP-set based on the linkage disequilibrium (LD) between SNPs, then assign a proper weight to each of the selected tag SNP respectively and test the joint effect of these weighted tag SNP

SUBMITTER: Yan B 

PROVIDER: S-EPMC4373116 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature